Details

Autor(en) / Beteiligte

• Marra, Marco A.
• Steven J. M. Jones
• Astell, Caroline R.
• Holt, Robert A.
• Brooks-Wilson, Angela
• Yaron S. N. Butterfield
• Khattra, Jaswinder
• Asano, Jennifer K.
• Barber, Sarah A.
• Chan, Susanna Y.
• Cloutier, Alison
• Coughlin, Shaun M.
• Freeman, Doug
• Girn, Noreen
• Griffith, Obi L.
• Leach, Stephen R.
• Mayo, Michael
• McDonald, Helen
• Montgomery, Stephen B.
• Pandoh, Pawan K.
• Petrescu, Anca S.
• Robertson, A. Gordon
• Schein, Jacqueline E.
• Siddiqui, Asim
• Smailus, Duane E.
• Stott, Jeff M.
• Yang, George S.
• Plummer, Francis
• Andonov, Anton
• Artsob, Harvey
• Bastien, Nathalie
• Bernard, Kathy
• Booth, Timothy F.
• Bowness, Donnie
• Czub, Martin
• Drebot, Michael
• Fernando, Lisa
• Flick, Ramon
• Garbutt, Michael
• Gray, Michael
• Grolla, Allen
• Jones, Steven
• Feldmann, Heinz
• Meyers, Adrienne
• Kabani, Amin
• Li, Yan
• Normand, Susan
• Stroher, Ute
• Tipples, Graham A.
• Tyler, Shaun
• Vogrig, Robert
• Ward, Diane
• Watson, Brynn
• Brunham, Robert C.
• Krajden, Mel
• Petric, Martin
• Skowronski, Danuta M.
• Upton, Chris
• Roper, Rachel L.

Titel

The Genome Sequence of the SARS-Associated Coronavirus

Ist Teil von

• Science (American Association for the Advancement of Science), 2003-05, Vol.300 (5624), p.1399-1404

Ort / Verlag

Washington, DC: American Association for the Advancement of Science

Erscheinungsjahr

2003

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)-associated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.