Science (American Association for the Advancement of Science), 2000-09, Vol.289 (5488), p.2344-2347
2000
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- Autor(en) / Beteiligte
- Titel
- Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling
- Ist Teil von
- Science (American Association for the Advancement of Science), 2000-09, Vol.289 (5488), p.2344-2347
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 2000
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene expression in liver, kidney, and heart. However, dexamethasone does not affect cyclic gene expression in neurons of the suprachiasmatic nucleus. This enabled us to establish an apparent phase-shift response curve specifically for peripheral clocks in intact animals. In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.289.5488.2344Titel-ID: cdi_proquest_miscellaneous_743429213
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Biological Clocks - physiology, Brain, Cell Cycle Proteins, Cell Line, Chronobiology, Circadian rhythm, Circadian Rhythm - physiology, Circadian rhythms, Dexamethasone, Dexamethasone - analogs & derivatives, Dexamethasone - pharmacology, DNA-Binding Proteins, Feedback (Response), Female, Fundamental and applied biological sciences. Psychology, Gene expression, Gene Expression Regulation - drug effects, Genes, Genetic engineering, Genetic mutation, Glucocorticoids, Inhalants, Kidney - metabolism, Kidneys, Liver, Liver - metabolism, Male, Messenger RNA, Mice, Mice, Inbred Strains, Molecular biology, Mutation, Myocardium - metabolism, Neurons, Neurons - metabolism, Nuclear Proteins - genetics, Nuclear Proteins - metabolism, Oscillators, Period Circadian Proteins, Phase shift, Physiology, Rats, Receptors, Glucocorticoid - genetics, Receptors, Glucocorticoid - metabolism, Signal Transduction, Solvents, Suprachiasmatic Nucleus - metabolism, Tissues, Transcription Factors - genetics, Transcription Factors - metabolism, Vertebrates: anatomy and physiology, studies on body, several organs or systems