Science (American Association for the Advancement of Science), 2002-05, Vol.296 (5569), p.879-883
2002
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Details
- Autor(en) / Beteiligte
- Titel
- Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila
- Ist Teil von
- Science (American Association for the Advancement of Science), 2002-05, Vol.296 (5569), p.879-883
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 2002
- Quelle
- Science Online_科学在线
- Beschreibungen/Notizen
- Animal cells exert exquisite control over the physical and chemical properties of their membranes, but the mechanisms are obscure. We show that phosphatidylethanolamine, the major phospholipid in Drosophila, controls the release of sterol regulatory element-binding protein (SREBP) from Drosophila cell membranes, exerting feedback control on the synthesis of fatty acids and phospholipids. The finding that SREBP processing is controlled by different lipids in mammals and flies (sterols and phosphatidylethanolamine, respectively) suggests that an essential function of SREBP is to monitor cell membrane composition and to adjust lipid synthesis accordingly.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1071124Titel-ID: cdi_proquest_miscellaneous_743416477
- Format
- –
- Schlagworte
- Animal cells, Animals, Biochemistry. Physiology. Immunology, Biological and medical sciences, CCAAT-Enhancer-Binding Proteins - genetics, CCAAT-Enhancer-Binding Proteins - metabolism, Cell Membrane - metabolism, Cell membranes, Cell Nucleus - metabolism, Cellular biology, Ceramides, Ceramides - metabolism, Ceramides - pharmacology, Cholesterol - metabolism, Cytology, DNA-Binding Proteins - genetics, DNA-Binding Proteins - metabolism, Double stranded RNA, Drosophila, Drosophila - genetics, Drosophila - metabolism, Drosophila Proteins - genetics, Drosophila Proteins - metabolism, Enzyme Inhibitors - pharmacology, Enzymes, Fatty acids, Fatty Acids - biosynthesis, Fatty Acids, Monounsaturated - pharmacology, Feedback, Physiological, Fundamental and applied biological sciences. Psychology, Gene Silencing, Inhibition, Insecta, Insects, Intracellular Signaling Peptides and Proteins, Invertebrates, Lipid synthesis, Lipids, Mammals, Membrane Lipids - biosynthesis, Membrane Proteins - metabolism, Membranes, Messenger RNA, Palmitates, Palmitates - metabolism, Palmitates - pharmacology, Phosphatidylcholines - biosynthesis, Phosphatidylethanolamines - biosynthesis, Phosphatidylethanolamines - metabolism, Phospholipids - biosynthesis, Physiology. Development, Proteins, RNA, Messenger - genetics, RNA, Messenger - metabolism, RNA, Small Interfering, RNA, Untranslated - pharmacology, SREBP protein, Sterol Regulatory Element Binding Protein 1, sterol regulatory element-binding protein, Studies, Synthesis, Transcription Factors - metabolism