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Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter
Ist Teil von
Science (American Association for the Advancement of Science), 2000-08, Vol.289 (5481), p.957-960
Ort / Verlag
Washington, DC: American Society for the Advancement of Science
Erscheinungsjahr
2000
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Previous work has identified two families of proteins that transport classical neurotransmitters into synaptic vesicles, but the protein responsible for vesicular transport of the principal excitatory transmitter glutamate has remained unknown. We demonstrate that a protein that is unrelated to any known neurotransmitter transporters and that was previously suggested to mediate the Na+-dependent uptake of inorganic phosphate across the plasma membrane transports glutamate into synaptic vesicles. In addition, we show that this vesicular glutamate transporter, VGLUT1, exhibits a conductance for chloride that is blocked by glutamate.