Science (American Association for the Advancement of Science), 2001-01, Vol.291 (5501), p.134-137
- Davis, Stephen T.
- Benson, Bill G.
- Bramson, H. Neal
- Chapman, Dennis E.
- Dickerson, Scott H.
- Dold, Karen M.
- Eberwein, Derek J.
- Edelstein, Mark
- Frye, Stephen V.
- Gampe, Robert T.
- Griffin, Robert J.
- Harris, Philip A.
- Hassell, Anne M.
- Holmes, William D.
- Hunter, Robert N.
- Knick, Victoria B.
- Lackey, Karen
- Lovejoy, Brett
- Luzzio, Michael J.
- Murray, Doris
- Parker, Patricia
- Rocque, Warren J.
- Shewchuk, Lisa
- Veal, James M.
- Walker, Duncan H.
- Kuyper, Lee F.
2001
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- Autor(en) / Beteiligte
- Davis, Stephen T.
- Benson, Bill G.
- Bramson, H. Neal
- Chapman, Dennis E.
- Dickerson, Scott H.
- Dold, Karen M.
- Eberwein, Derek J.
- Edelstein, Mark
- Frye, Stephen V.
- Gampe, Robert T.
- Griffin, Robert J.
- Harris, Philip A.
- Hassell, Anne M.
- Holmes, William D.
- Hunter, Robert N.
- Knick, Victoria B.
- Lackey, Karen
- Lovejoy, Brett
- Luzzio, Michael J.
- Murray, Doris
- Parker, Patricia
- Rocque, Warren J.
- Shewchuk, Lisa
- Veal, James M.
- Walker, Duncan H.
- Kuyper, Lee F.
- Titel
- Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors
- Ist Teil von
- Science (American Association for the Advancement of Science), 2001-01, Vol.291 (5501), p.134-137
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 2001
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents. Potent small-molecule inhibitors of CDK2 were developed using structure-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.291.5501.134Titel-ID: cdi_proquest_miscellaneous_743395507
- Format
- –
- Schlagworte
- Alopecia, Alopecia - chemically induced, Alopecia - prevention & control, Animals, Animals, Newborn, Antineoplastic Agents - toxicity, Antineoplastic Combined Chemotherapy Protocols - toxicity, Antineoplastics, Apoptosis - drug effects, Atoms, Baldness, Biological and medical sciences, Cancer, CDC2-CDC28 Kinases, Cdk2 kinase, Cell cycle, Cell Cycle - drug effects, Cell Line, Chemotherapy, Complications and side effects, Cyclin-Dependent Kinase 2, cyclin-dependent kinase inhibitors, Cyclin-Dependent Kinases - antagonists & inhibitors, Cyclin-Dependent Kinases - metabolism, Cyclins, Cyclophosphamide - toxicity, Cytoprotection - drug effects, DNA - biosynthesis, Doxorubicin - toxicity, Drug Design, Drug therapy, Drug toxicity and drugs side effects treatment, Enzyme Inhibitors - chemical synthesis, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, Epithelial cells, Epithelium - drug effects, Etoposide - toxicity, Hair, Hair Follicle - cytology, Hair Follicle - drug effects, Hair follicles, Humans, Indoles - chemical synthesis, Indoles - chemistry, Indoles - pharmacology, Inhibition, Medical sciences, Mice, Mice, SCID, Narcotics, Pharmacology. Drug treatments, Phosphorylation, Prevention, Protein-Serine-Threonine Kinases - antagonists & inhibitors, Protein-Serine-Threonine Kinases - metabolism, Rats, Retinoblastoma Protein - metabolism, Rodents, Scalp, Scalp - transplantation, Sulfonamides - chemical synthesis, Sulfonamides - chemistry, Sulfonamides - pharmacology, Toxicity: skin, dermoskeleton, Transplantation, Heterologous