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Prospects for Building the Tree of Life from Large Sequence Databases
Ist Teil von
Science (American Association for the Advancement of Science), 2004-11, Vol.306 (5699), p.1172-1174
Ort / Verlag
Washington, DC: American Association for the Advancement of Science
Erscheinungsjahr
2004
Link zum Volltext
Quelle
American Association for the Advancement of Science
Beschreibungen/Notizen
We assess the phylogenetic potential of ~300,000 protein sequences sampled from Swiss-Prot and GenBank. Although only a small subset of these data was potentially phylogenetically informative, this subset retained a substantial fraction of the original taxonomic diversity. Sampling biases in the databases necessitate building phylogenetic data sets that have large numbers of missing entries. However, an analysis of two "supermatrices" suggests that even data sets with as much as 92% missing data can provide insights into broad sections of the tree of life.