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  • BibTeX
Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid
Science (American Association for the Advancement of Science), 2004-06, Vol.304 (5677), p.1644-1647
2004

Details

Autor(en) / Beteiligte
Titel
Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid
Ist Teil von
  • Science (American Association for the Advancement of Science), 2004-06, Vol.304 (5677), p.1644-1647
Ort / Verlag
Washington, DC: American Association for the Advancement of Science
Erscheinungsjahr
2004
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
  • Cells regulate the biophysical properties of their membranes by coordinated synthesis of different classes of lipids. Here, we identified a highly dynamic feedback mechanism by which the budding yeast Saccharomyces cerevisiae can regulate phospholipid biosynthesis. Phosphatidic acid on the endoplasmic reticulum directly bound to the soluble transcriptional repressor Opi1p to maintain it as inactive outside the nucleus. After the addition of the lipid precursor inositol, this phosphatidic acid was rapidly consumed, releasing Opi1p from the endoplasmic reticulum and allowing its nuclear translocation and repression of target genes. Thus, phosphatidic acid appears to be both an essential ubiquitous metabolic intermediate and a signaling lipid.
Sprache
Englisch
Identifikatoren
ISSN: 0036-8075
eISSN: 1095-9203
DOI: 10.1126/science.1096083
Titel-ID: cdi_proquest_miscellaneous_743370054
Format
–
Schlagworte
Active Transport, Cell Nucleus, acyltransferases, Animals, Binding Sites, Biological and medical sciences, Biophysics, Brewer's yeast, Cell Membrane - metabolism, Cell membranes, cell nucleus, Cell Nucleus - metabolism, Cellular biology, Chlorocebus aethiops, COS Cells, Cytidine Diphosphate Diglycerides - metabolism, endoplasmic reticulum, Endoplasmic Reticulum - metabolism, Fundamental and applied biological sciences. Psychology, gene expression regulation, Genetic aspects, Glycerophospholipids, Inositol - metabolism, Inositols, Lipid metabolism, Lipids, Lipids. Glycolipids, lipogenesis, Liposomes - metabolism, membrane proteins, Memory interference, Metabolism, Metabolisms and neurohumoral controls, Mutation, myo-inositol, Nuclear Envelope - metabolism, Phosphatidic Acids - metabolism, phosphatidylinositol synthase, Phosphatidylinositols - metabolism, Phospholipids, Phospholipids - biosynthesis, Phospholipids - metabolism, Physiological aspects, Properties, protein binding, protein transport, Recombinant Fusion Proteins - metabolism, Repressor Proteins - chemistry, Repressor Proteins - genetics, Repressor Proteins - metabolism, Saccharomyces cerevisiae, Saccharomyces cerevisiae - genetics, Saccharomyces cerevisiae - metabolism, Saccharomyces cerevisiae Proteins - chemistry, Saccharomyces cerevisiae Proteins - genetics, Saccharomyces cerevisiae Proteins - metabolism, Signal Transduction, Transcription factors, Vertebrates: anatomy and physiology, studies on body, several organs or systems, Yeasts

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