Science (American Association for the Advancement of Science), 2001-07, Vol.293 (5528), p.300-303
2001
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Details
- Autor(en) / Beteiligte
- Titel
- Impairment of Mycobacterial but Not Viral Immunity by a Germline Human STAT1 Mutation
- Ist Teil von
- Science (American Association for the Advancement of Science), 2001-07, Vol.293 (5528), p.300-303
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 2001
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Interferons (IFN) α/β and γ induce the formation of two transcriptional activators: gamma-activating factor (GAF) and interferon-stimulated gamma factor 3 (ISGF3). We report a natural heterozygous germline STAT1 mutation associated with susceptibility to mycobacterial but not viral disease. This mutation causes a loss of GAF and ISGF3 activation but is dominant for one cellular phenotype and recessive for the other. It impairs the nuclear accumulation of GAF but not of ISGF3 in heterozygous cells stimulated by IFNs. Thus, the antimycobacterial, but not the antiviral, effects of human IFNs are principally mediated by GAF.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1061154Titel-ID: cdi_proquest_miscellaneous_743296725
- Format
- –
- Schlagworte
- Adult, Alleles, Analysis of the immune response. Humoral and cellular immunity, Animals, Antibodies, Bacteria, Bacteriology, Biological and medical sciences, Cell Line, Cell lines, Child, Child, Preschool, Coding, DNA - metabolism, DNA-Binding Proteins - genetics, DNA-Binding Proteins - physiology, Etiology, Female, Fibroblasts, Fibroblasts - metabolism, Fibroblasts - virology, Fundamental and applied biological sciences. Psychology, Fundamental immunology, GAF protein, gamma-activating factor, Gene Expression Regulation, Genetic mutation, Germ-Line Mutation, Humans, Immunity, Immunity - genetics, Immunobiology, Immunology, Infections, Interferon-alpha - immunology, Interferon-alpha - metabolism, Interferon-gamma - immunology, Interferon-gamma - metabolism, Interferon-Stimulated Gene Factor 3, Interferon-Stimulated Gene Factor 3, gamma Subunit, ISGF3 protein, Janus Kinase 1, Mice, Microbiology, Miscellaneous, Mutation, Mycobacterial infections, Mycobacterium, Mycobacterium avium Complex - immunology, Mycobacterium avium-intracellulare Infection - genetics, Mycobacterium avium-intracellulare Infection - immunology, Mycobacterium bovis, Mycobacterium infections, Mycobacterium Infections - genetics, Mycobacterium Infections - immunology, Neurons, Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains, Patients, Pedigree, Protein Binding, Protein-Tyrosine Kinases - genetics, Regulatory factors and their cellular receptors, Signal Transduction, Simian virus 40, STAT1 Transcription Factor, T lymphocytes, Trans-Activators - genetics, Trans-Activators - physiology, Transcription Factors - physiology, Virus Diseases - genetics, Virus Diseases - immunology, Viruses