Science (American Association for the Advancement of Science), 2004-04, Vol.304 (5671), p.728-730
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Illuminating the Evolutionary History of Chlamydiae
- Ist Teil von
- Science (American Association for the Advancement of Science), 2004-04, Vol.304 (5671), p.728-730
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2004
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Chlamydiae are the major cause of preventable blindness and sexually transmitted disease. Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is twice as large as any of the pathogenic chlamydiae and had few signs of recent lateral gene acquisition. We showed that about 700 million years ago the last common ancestor of pathogenic and symbiotic chlamydiae was already adapted to intracellular survival in early eukaryotes and contained many virulence factors found in modern pathogenic chlamydiae, including a type III secretion system. Ancient chlamydiae appear to be the originators of mechanisms for the exploitation of eukaryotic cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1096330Titel-ID: cdi_proquest_miscellaneous_743260346
- Format
- –
- Schlagworte
- Acanthamoeba - microbiology, Analysis, Animals, Bacteria, Bacterial Proteins - analysis, Bacterial Proteins - genetics, Bacterial Proteins - metabolism, Bacteriology, Biochemical pathways, Biological and medical sciences, Biological Evolution, Cell Membrane - chemistry, Cell Wall - chemistry, Chlamydia, Chlamydia - classification, Chlamydia - genetics, Chlamydia - metabolism, Chlamydia - pathogenicity, Chlamydiales - classification, Chlamydiales - genetics, Chlamydiales - metabolism, Chlamydiales - pathogenicity, Chlamydophila - classification, Chlamydophila - genetics, Chlamydophila - metabolism, Chlamydophila - pathogenicity, Chronic illnesses, Coding, Electron Transport, Environmental conservation, Eukaryotic cells, Evolution, Fundamental and applied biological sciences. Psychology, Gene Order, Gene Transfer, Horizontal, Genes, Genes, Bacterial, Genetic aspects, Genetic research, Genetics, Genome, Bacterial, Genomes, Microbiology, Molecular Sequence Data, Nucleotide Transport Proteins - metabolism, Nucleotides, Origin, Pathogens, Phylogenetics, Phylogeny, Sexually transmitted diseases, STD, Symbiosis, Virulence, Virulence Factors - genetics, Virulence Factors - metabolism