Science (American Association for the Advancement of Science), 2001-02, Vol.291 (5508), p.1523-1527
2001
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Details
- Autor(en) / Beteiligte
- Titel
- Automated Solid-Phase Synthesis of Oligosaccharides
- Ist Teil von
- Science (American Association for the Advancement of Science), 2001-02, Vol.291 (5508), p.1523-1527
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 2001
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Traditionally, access to structurally defined complex carbohydrates has been very laborious. Although recent advancements in solid-phase synthesis have made the construction of complex oligosaccharides less tedious, a high level of technical expertise is still necessary to obtain the desired structures. We describe the automated chemical synthesis of several oligosaccharides on a solid-phase synthesizer. A branched dodecasaccharide was synthesized through the use of glycosyl phosphate building blocks and an octenediol functionalized resin. The target oligosaccharide was readily obtained after cleavage from the solid support. Access to certain complex oligosaccharides now has become feasible in a fashion much like the construction of oligopeptides and oligonucleotides.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1057324Titel-ID: cdi_proquest_miscellaneous_743234771
- Format
- –
- Schlagworte
- Automation, Carbohydrate Conformation, Carbohydrate Sequence, Carbohydrates, Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides, Carbohydrates. Nucleosides and nucleotides, Chemistry, Chemistry, Organic - instrumentation, Chemistry, Organic - methods, Donors, Esters, Exact sciences and technology, Glucans - chemical synthesis, Glucans - chemistry, Glycogen, Glycogen synthesis, Glycosylation, Hydroxyls, Molecular Sequence Data, Nuclear Magnetic Resonance, Biomolecular, Oligosaccharides, Oligosaccharides - chemical synthesis, Oligosaccharides - chemistry, Oligosaccharides - isolation & purification, Organic Chemistry, Peptides, Phosphates, Polymers, Preparations and properties, Resins, Resins, Plant, Shergottites, Synthesis, Synthesizers, Temperature, Trisaccharides