Science (American Association for the Advancement of Science), 2007-04, Vol.316 (5824), p.612-616
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation
- Ist Teil von
- Science (American Association for the Advancement of Science), 2007-04, Vol.316 (5824), p.612-616
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2007
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8⁺ effector T cells (cross-presentation) or to CD4⁺ T helper cells are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to simultaneously introduce soluble antigen into separate intracellular compartments, which were dedicated to presentation to CD8⁺ or CD4⁺ T cells. Specifically, the mannose receptor supplied an early endosomal compartment distinct from lysosomes, which was committed to cross-presentation. These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1137971Titel-ID: cdi_proquest_miscellaneous_743183609
- Format
- –
- Schlagworte
- Animals, Antigen Presentation, Antigens, Antigens - immunology, Binding sites, Biological and medical sciences, CD4-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - immunology, Cellular biology, Cross priming, Dendritic Cells - immunology, Endocytosis, Endosomes, Endosomes - immunology, Endosomes - metabolism, Fluorescence, Fundamental and applied biological sciences. Psychology, Fundamental immunology, Genetics of the immune response, Histocompatibility Antigens Class II - immunology, Immunobiology, Immunology, Lectins, C-Type - metabolism, Lymphocyte Activation, Lysosomes, Lysosomes - immunology, Lysosomes - metabolism, Macrophages - immunology, Mannose-Binding Lectins - metabolism, Mice, Mice, Inbred C57BL, Models, Immunological, Molecules, Ova, Ovalbumin - immunology, Pinocytosis, Receptors, Receptors, Cell Surface - metabolism, Receptors, Scavenger - metabolism, T lymphocytes