Science (American Association for the Advancement of Science), 2002-10, Vol.298 (5591), p.176-178
2002
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Details
- Autor(en) / Beteiligte
- Titel
- G Protein-Coupled Receptors in Anopheles gambiae
- Ist Teil von
- Science (American Association for the Advancement of Science), 2002-10, Vol.298 (5591), p.176-178
- Ort / Verlag
- United States: American Association for the Advancement of Science
- Erscheinungsjahr
- 2002
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1076196Titel-ID: cdi_proquest_miscellaneous_743163527
- Format
- –
- Schlagworte
- Algorithms, Alternative Splicing, Amino Acid Sequence, Amino acids, Animals, Anopheles, Anopheles - chemistry, Anopheles - genetics, Anopheles - metabolism, Anopheles gambiae, Biological taxonomies, Computational Biology, Conserved Sequence, Culicidae, Drosophila melanogaster, Drosophila melanogaster - chemistry, Drosophila melanogaster - genetics, Drosophila melanogaster - metabolism, Drosophila Proteins - chemistry, Drosophila Proteins - genetics, Drosophila Proteins - metabolism, Evolution, Molecular, Family (Sociological Unit), Freshwater, Gene Amplification, Gene Expression, Genes, Insect, Genetic aspects, Genome, Genomes, Genomics, GTP-Binding Proteins - metabolism, Insect Proteins - chemistry, Insect Proteins - genetics, Insect Proteins - metabolism, Life cycles, Ligands, Malaria, Molecular Sequence Data, Mosquitoes, Mosquitos, Multigene Family, Neurons, odorant receptors, Opsins, Orphans, Phylogeny, Proteins, Receptors, Receptors, Cell Surface - chemistry, Receptors, Cell Surface - genetics, Receptors, Cell Surface - metabolism, Receptors, Odorant - chemistry, Receptors, Odorant - genetics, Receptors, Odorant - metabolism, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction