Science (American Association for the Advancement of Science), 2004-05, Vol.304 (5672), p.878-880
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Cognitive Inflexibility after Prefrontal Serotonin Depletion
- Ist Teil von
- Science (American Association for the Advancement of Science), 2004-05, Vol.304 (5672), p.878-880
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2004
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Serotonergic dysregulation within the prefrontal cortex (PFC) is implicated in many neuropsychiatric disorders, but the precise role of serotonin within the PFC is poorly understood. Using a serial discrimination reversal paradigm, we showed that upon reversal, selective serotonin depletion of the marmoset PFC produced perseverative responding to the previously rewarded stimulus without any significant effects on either retention of a discrimination learned preoperatively or acquisition of a novel discrimination postoperatively. These results highlight the importance of prefrontal serotonin in behavioral flexibility and are highly relevant to obsessive-compulsive disorder, schizophrenia, and the cognitive sequelae of drug abuse in which perseveration is prominent.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1094987Titel-ID: cdi_proquest_miscellaneous_743121058
- Format
- –
- Schlagworte
- 5,7-Dihydroxytryptamine - administration & dosage, 5,7-Dihydroxytryptamine - pharmacology, Adult and adolescent clinical studies, Animals, Anxiety Disorders, Behavior, Animal, Behavioral neuroscience, Biological and medical sciences, Brain - metabolism, Brain chemistry, Brain research, Callithrix, Cognition, Cognition & reasoning, Control Groups, Discrimination Learning, Dopamine - metabolism, Error rates, Female, Forebrain, Frontal Lobe - metabolism, Fundamental and applied biological sciences. Psychology, Group Dynamics, Gyrus Cinguli - metabolism, Hydroxyindoleacetic Acid - metabolism, Lesions, Male, Medical sciences, Mental Disorders, Motor cortex, Motor Cortex - metabolism, Neurological disorders, Neurotransmitters, Norepinephrine - metabolism, Obsessive compulsive disorder, Oxidopamine - pharmacology, Physiological aspects, Prefrontal Cortex - metabolism, Prefrontal Cortex - physiology, Psychology. Psychoanalysis. Psychiatry, Psychomotor Performance, Psychopathology, Psychopathology. Psychiatry, Psychoses, Reward, Schizophrenia, Sensory discrimination, Serotonin, Serotonin - metabolism, Serotonin - physiology, Serotonin agents, Serotonin receptors, Short Term Memory, Statistical Analysis, Surgery, Vertebrates: nervous system and sense organs, Visual Discrimination