Science (American Association for the Advancement of Science), 2003-10, Vol.302 (5644), p.445-449
2003
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- Autor(en) / Beteiligte
- Titel
- Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases
- Ist Teil von
- Science (American Association for the Advancement of Science), 2003-10, Vol.302 (5644), p.445-449
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2003
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- The Rho guanosine triphosphatases (GTPases) Rad and Rac1 are critical signaling regulators in mammalian cells. The deletion of both Rac1 and Rac2 murine alleles leads to a massive egress of hematopoietic stem/progenitor cells (HSC/Ps) into the blood from the marrow, whereas$Rac1^{-/-}$but not Rac2-/-HSC/Ps fail to engraft in the bone marrow of irradiated recipient mice. In contrast, Rac2, but not Rac1, regulates superoxide production and directed migration in neutrophils, and in each cell type, the two GTPases play distinct roles in actin organization, cell survival, and proliferation. Thus, Rad and Rac2 regulate unique aspects of hematopoietic development and function.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1088485Titel-ID: cdi_proquest_miscellaneous_743083305
- Format
- –
- Schlagworte
- Actins, Actins - metabolism, Animals, Antibodies, Apoptosis, Biological and medical sciences, Blood cells, Bone marrow, Bone Marrow Transplantation, Cell Adhesion, Cell Cycle, Cell differentiation, maturation, development, hematopoiesis, Cell growth, Cell Movement, Cell physiology, Cell regulation, Cell Size, Cells, Cellular biology, Cellular control mechanisms, Chemical properties, Colony-Forming Units Assay, Cyclin D1 - metabolism, Fibronectins - metabolism, Fundamental and applied biological sciences. Psychology, Gene expression regulation, Genotypes, GTPases, Guanosine triphosphatase, Hematopoiesis, Hematopoietic Stem Cell Mobilization, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells - physiology, Leukocytes, Mice, Mice, Inbred NOD, Mice, SCID, Mitogen-Activated Protein Kinases - metabolism, Molecular and cellular biology, Neutrophils, Neutrophils - physiology, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins - metabolism, Proto-Oncogene Proteins c-akt, rac GTP-Binding Proteins - genetics, rac GTP-Binding Proteins - metabolism, rac1 GTP-Binding Protein - genetics, rac1 GTP-Binding Protein - metabolism, RAC2 GTP-Binding Protein, Recombination, Genetic, Signal Transduction, Stem Cell Factor - pharmacology, Stem cells, Superoxides - metabolism