Biochimie, 1982-08, Vol.64 (8), p.717-721
1982
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Details
- Autor(en) / Beteiligte
- Titel
- An adaptive response to the cytotoxic effects of N-methyl- N-nitrosourea is apparently absent in normal human fibroblasts
- Ist Teil von
- Biochimie, 1982-08, Vol.64 (8), p.717-721
- Ort / Verlag
- France: Elsevier Masson SAS
- Erscheinungsjahr
- 1982
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- The authors have attempted to induce an adaptive response in human fibroblasts by multiple treatments with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The ability of treated cells to withstand a challenge by N-methyl-N-nitrosourea (MNU)was determined by cell survival (colony forming ability) and the induction of mironuclei. In addition, the authors have assayed two enzymes which are involved in the repair of methylation damage to DNA: O super(6)-methylguanine methyltransferase and 3-methyladenine-DNA glycosylase.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0300-9084eISSN: 1638-6183DOI: 10.1016/S0300-9084(82)80117-XTitel-ID: cdi_proquest_miscellaneous_74305656
- Format
- –
- Schlagworte
- adaptive response, alkylation, Cell Line, Cell Survival - drug effects, cellules humaines, DNA Glycosylases, DNA repair, Enzyme Induction, Fibroblasts - drug effects, human cells, Humans, Methylnitrosourea - pharmacology, Methyltransferases - metabolism, N-Glycosyl Hydrolases - metabolism, Nitrosourea Compounds - pharmacology, O-Methylguanine-DNA Methyltransferase, réparation du DNA, réponse adaptative