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BibTeX
Bayesian methods in cost-effectiveness studies: objectivity, computation and other relevant aspects
Health economics, 2010-06, Vol.19 (6), p.629-643
Armero, C.
García-Donato, G.
López-Quílez, A.
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Armero, C.
García-Donato, G.
López-Quílez, A.
Titel
Bayesian methods in cost-effectiveness studies: objectivity, computation and other relevant aspects
Ist Teil von
Health economics, 2010-06, Vol.19 (6), p.629-643
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2010
Quelle
Applied Social Sciences Index & Abstracts (ASSIA)
Beschreibungen/Notizen
In a probabilistic sensitivity analysis (PSA) of a cost–effectiveness (CE) study, the unknown parameters are considered as random variables. A crucial question is what probabilistic distribution is suitable for synthesizing the available information (mainly data from clinical trials) about these parameters. In this context, the important role of Bayesian methodology has been recognized, where the parameters are of a random nature. We explore, in the context of CE analyses, how formal objective Bayesian methods can be implemented. We fully illustrate the methodology using two CE problems that frequently appear in the CE literature. The results are compared with those obtained with other popular approaches to PSA. We find that the discrepancies can be quite marked, specially when the number of patients enrolled in the simulated cohort under study is large. Finally, we describe in detail the numerical methods that need to be used to obtain the results. Copyright © 2009 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 1057-9230
eISSN: 1099-1050
DOI: 10.1002/hec.1496
Titel-ID: cdi_proquest_miscellaneous_742725462
Format
–
Schlagworte
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Anti-Inflammatory Agents, Non-Steroidal - economics
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Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
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Bayes Theorem
,
Bayesian analysis
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Clinical trials
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Comparative analysis
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Cost analysis
,
Cost effectiveness
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Cost-Benefit Analysis - methods
,
cost-effectiveness studies
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Decision Support Techniques
,
Discrepancies
,
Health economics
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Humans
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Markov Chains
,
Methodology
,
Monte Carlo Method
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objective Bayesian methods
,
Objectivity
,
Osteoarthritis - drug therapy
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Osteoarthritis - economics
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Parameters
,
probabilistic sensitivity analysis
,
Probability distribution
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Random variables
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Sensitivity analysis
,
Studies
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