Details

Autor(en) / Beteiligte

• Lagunas-Solar, Manuel C.
• Little, Frank E.
• Moore, Herbert A.

Titel

Cyclotron production of 128Cs (3.62 min). A new positron-emitting radionuclide for medical applications

Ist Teil von

• The International journal of applied radiation and isotopes, 1982-08, Vol.33 (8), p.619-628

Ort / Verlag

United States: Elsevier B.V

Erscheinungsjahr

1982

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The cyclotron production of the short-lived positron emitter 128Cs (3.62 min) from its longer-lived parent 128Ba (2.42 d), based upon the 133Cs(p, 6n) 128Ba→ 128Cs reaction ( Q = −43.98 MeV), has been studied. Cesium-128 has potential applications in positron tomography, particularly for imaging the myocardium and/or for the assessment of regional blood flow. Thick-target yields (mCi/μAh) and cross sections (mb) for 128Ba, 131Ba, 129Cs and 132Cs were measured in the 67-36 MeV proton-energy region. Cyclotron production of 128Ba- 128Cs (transient equilibrium) was measured as 3.1 mCi/μAh at end of bombardment (EOB) with a 2.32 g cm −2 thick CsCl target with a proton entrance energy of 67 MeV and exit energy of 54 MeV. Target-radiochemistry using ion-exchange methods allow the preparation of a generator-type system from which high-radionuclidic purity, radiopharmaceutical quality, no-carrier-added 128Cs can be obtained for immediate administration. In addition, with proper radiochemical handling of the 128Ba 128Cs generator, no-carrier-added, high-purity 129Cs (32.35 h, 372 keV, 32%) can also be produced for use in research applications.