Details

Autor(en) / Beteiligte

• Koechel, Daniel A
• Rankin, Gary O

Titel

Diuretic activity of Mannich base derivatives of ethacrynic acid and certain ethacrynic acid analogs

Ist Teil von

• Journal of medicinal chemistry, 1978-08, Vol.21 (8), p.764-769

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

1978

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Various Mannich base derivatives of selected phenoxyacetic acid type diuretics were synthesized and their diuretic potency was evaluated in dogs. It is concluded that the Mannich bases possess little, if any, diuretic activity of their own. Those Mannich bases that do possess diuretic activity undoubtedly do so as a consequence of an elimination reaction (a retro-Michael type reaction) which yields the corresponding pharmacologically active alpha,beta-unsaturated ketone.