Science (American Association for the Advancement of Science), 1982-08, Vol.217 (4559), p.549-552
1982
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Details
- Autor(en) / Beteiligte
- Titel
- Diverse Mechanisms in the Generation of Human β-Tubulin Pseudogenes
- Ist Teil von
- Science (American Association for the Advancement of Science), 1982-08, Vol.217 (4559), p.549-552
- Ort / Verlag
- United States: The American Association for the Advancement of Science
- Erscheinungsjahr
- 1982
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The sequence of two human β-tubulin pseudogenes is described. One contains an intervening sequence but lacks sequences encoding the 55 N-terminal amino acids of the polypeptide chain. A second has no introns but has a polyadenylate signal and an oligoadenylate tract at its 3′ end, and it is flanked by a short direct repeat. These sequences have arisen by different mechanisms, including one that probably involves reverse transcription of a processed messenger RNA and reintegration of the complementary DNA copy into the genome.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.6178164Titel-ID: cdi_proquest_miscellaneous_74109331
- Format
- –
- Schlagworte
- Amino acids, Base Sequence, Complementary DNA, DNA, DNA - analysis, DNA Restriction Enzymes, DNA Transposable Elements, DNA, Recombinant, Gene Expression Regulation, Genes, Genetic transcription, Genomes, Human genetics, Humans, Introns, Messenger RNA, Nucleic Acid Hybridization, Poly A - genetics, Pseudogenes, Recombination, Genetic, Reverse transcription, Ribonucleic acid metabolism, RNA Splicing, RNA-Directed DNA Polymerase - metabolism, Spider webs, Transcription (Genetics), Tubulin - genetics