Details

Autor(en) / Beteiligte

• Drake, R E
• Adcock, D K
• Scott, R L
• Gabel, J C

Titel

Effect of Outflow Pressure upon Lymph Flow from Dog Lungs

Ist Teil von

• Circulation research, 1982-06, Vol.50 (6), p.865-869

Ort / Verlag

United States: American Heart Association, Inc

Erscheinungsjahr

1982

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• The pulmonary lymph flow rate (QL) should be a function of the lymph vesselsʼ resistance and the pressure gradient along the vessels. We attempted to study how these factors affect lymph flow. We assumed that the lymph system could be represented by a single pressure generated within the lung (PL) and a single resistance (RiJ. Thus, Q L should be a function of the lymph vessel outflow pressure (Po)Q L = (Pi. - PO)/RL- We cannulated tracheobronchial lymph vessels in eight anesthetized dogs and varied Po by raising the outflow end of the cannula. Q L decreased linearly when we increased Po. We estimated RL as - ΔPO/ΔQL and PL as the extrapolated Po at which QL = 0. At baseline PL = 7.7 ± 2.7 (SD) cm H2O and RL = 0.36 ± 0.25 cm H2O-min/ il. After we increased capillary pressure to produce edema, PL and RL averaged 22.8 ± 8.8 and 0.14 ± 0.12, respectively. After we reduced the capillary pressure to baseline in the edematous lungs, PL and RL averaged 11.6 ± 2.8 and 0.08 ± 0.09, respectively. All changes in Pi, and Ri, were significant (P < 0.05). These results show that (1) lymph flow rate depends upon lymph vessel outflow pressure, and (2) the QL VS. PO relationship is changed by edema. PL may be equal to the pressure causing lymph to flow and Ri. may equal the lymph vessel resistance.