Details

Autor(en) / Beteiligte

• Chau, Nguyen Ph
• Zech, Paul Y
• Pozet, Nicole
• Hadj‐Aissa, Aoumeur

Titel

Ranitidine kinetics in normal subjects

Ist Teil von

• Clinical pharmacology and therapeutics, 1982-06, Vol.31 (6), p.770-774

Ort / Verlag

United States

Erscheinungsjahr

1982

Quelle

MEDLINE

Beschreibungen/Notizen

• A 1‐mg/kg IV bolus injection and a 150‐mg (one tablet) oral dose of ranitidine were given to seven normal subjects. At least 1 wk separated the two doses. Ranitidine disappeared from plasma with a half‐life of about 2.5 hr. Half of the oral dose was effectively absorbed and half of the absorbed amount was found unchanged in urine. Total body clearance was 10.1 ml/min/kg. Urinary clearance was the same after oral and intravenous doses (6.4 and 6.9 ml/min/kg, P > 0.10). Intravenous ranitidine kinetics included three phases, with a central distribution volume of 0.2 l/kg and a total distribution volume of 1.2 l/kg. Absorption kinetics were apparently order zero: of the 150‐mg dose, 75 mg was absorbed during 5 hr at a constant rate of 15 mg/hr. Clinical Pharmacology and Therapeutics (1982) 31, 770–774; doi:10.1038/clpt.1982.109