Chemical and Pharmaceutical Bulletin, 1978/04/25, Vol.26(4), pp.1135-1140
1978
Details
- Autor(en) / Beteiligte
- Titel
- Tissue Distribution and Metabolism of Drugs. II. Accumulation and Permeation of Drugs in the Rabbit Pancreas
- Ist Teil von
- Chemical and Pharmaceutical Bulletin, 1978/04/25, Vol.26(4), pp.1135-1140
- Ort / Verlag
- Japan: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 1978
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Tissue distribution and penetration of drugs were measured in the rabbit pancreas cannulated into the pancreatic duct for the collection of pancreatic juice. Drugs with high lipid solubility were found to be easily distributed within the pancreas. The lipid solubility of drugs appears to be the most important factors determining their distribution in the pancreas. Small molecules were rapidly penetrated from blood to pancreatic juice if they are lipid soluble. Permeability of drugs through the pancreas was demonstrated to be dependent upon their molecular size and lipid solubility. Increased penetration of drugs by the retrograde infusion of HgCl2 solution through the pancreatic duct suggested that both lipid barrier and molecular sieve barrier would be complex multicellular system and exist independently surrounding the pancreatic duct.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-2363eISSN: 1347-5223DOI: 10.1248/cpb.26.1135Titel-ID: cdi_proquest_miscellaneous_74024650
- Format
- –
- Schlagworte
- Animals, Cell Membrane Permeability, Dimethadione - metabolism, Isonicotinic Acids - metabolism, Lipids, mercuric chloride, Pancreas - metabolism, Pancreatic Juice - metabolism, Pharmaceutical Preparations - metabolism, Procainamide - metabolism, Rabbits, Solubility, Sulfanilamides - metabolism, Sulfisomidine - metabolism, Tissue Distribution