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The pathological status of internal mammary chains at the time of presentation in patients with carcinoma of the breast carries important prognostic significance. The aggressive treatment of involved nodes may alter the course of disease favourably in terms of survival and local recurrence. Methods of accurately localising and assessing the state of the internal mammary chain have been described previously. We present here the preliminary results of a series of patients studied with radioisotope techniques to assess anatomy and status of the nodes with special reference to radiotherapy planning.