Details

Autor(en) / Beteiligte

• SAEKI, Y
• OHSHIMA, S
• MIMA, T
• SASAI, M
• NISHIOKA, K
• SHIMIZU, M
• SUEMURA, M
• MCCLOSKEY, R
• KISHIMOTO, T

Titel

Suboptimal clinical response to anti-tumor necrosis factor alpha (TNFα) antibody therapy in a patient with severe rheumatoid arthritis and lymphadenopathy

Ist Teil von

• Scandinavian journal of rheumatology, 1998, Vol.27 (4), p.303-305

Ort / Verlag

Colchester: Taylor & Francis

Erscheinungsjahr

1998

Quelle

Taylor & Francis

Beschreibungen/Notizen

• This concerns a patient with severe rheumatoid arthritis (RA) and lymphadenopathy (LA) who showed suboptimal clinical response to antitumor necrosis factor alpha (TNFalpha) antibody (Ab), cA2 therapy. The assessment of TNFalpha and IL-6 mRNA expression in the swollen lymph-node (LN) of the patient by reverse transcription, polymerase chain reaction (RT-PCR) before cA2 treatment, showed only enhanced IL-6 production, but not TNFalpha. Moreover, cA2 failed to inhibit in-vitro spontaneous IL-6 production in the LN block culture from the patient. Taken together, these results indicate that IL-6 production in the swollen LNs of the patient might not depend on TNFalpha. This might partly cause suboptimal clinical response to anti-TNFalpha Ab therapy in the patient.