Details

Autor(en) / Beteiligte

• Garciéa-Riéo, Francisco
• Pino-Garciéa, José M.
• Racionero, Miguel A.
• Terreros-Caro, Javier G.
• Goémez-Mendieta, Mariéa A.
• Prados, Concepcioén
• Villasante, Carlos

Titel

Long-term Within-Subject Variability of Inspiratory Neural Drive Response to Hypoxia

Ist Teil von

• Chest, 1998-08, Vol.114 (2), p.521-525

Ort / Verlag

Northbrook, IL: Elsevier Inc

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• We analyze the within-subject variation of mouth occlusion pressure (P0.1) response to progressive isocapnic hypoxic stimulation over long time periods in normal subjects. We studied 21 healthy subjects (14 male and 7 female; aged 40±12 yrs) (mean±SD). Lung volumes, basal P0.1, and P0.1 response to hypoxia were measured on two separate occasions 2 months apart, under similar ambient and clinical conditions. There was no significant change in clinical condition, FVC, FEV1, arterial oxygenation saturation, end-tidal and mixed venous Pco2 levels, or P0.1 between the two visits. The mean P0.1 responses to hypoxia in the two explorations were 0.032±0.022 and 0.034±0.022 kPa/%, respectively. There was a moderate intrasubject variability of P0.1 response to hypoxia, with a coefficient of reproducibility of 0.01 kPa/%. Power calculations to establish the optimal sample size required for hypoxic stimulation are presented. Long term within-subject variability of P0.1 response to hypoxia is moderate. This intrinsic variability needs to be emphasized when interpreting the effects of experimental interventions on hypoxic sensitivity.