Details

Autor(en) / Beteiligte

• Castles, James J.
• Gershwin, M. Eric
• Saito, Wilfred
• Ardans, Alex
• Osburn, Bennie

Titel

The activity of purine salvage pathway enzymes in murine and horse models of congenital and acquired dysimmunity

Ist Teil von

• Developmental and comparative immunology, 1977-04, Vol.1 (2), p.165-173

Ort / Verlag

United States: Elsevier Ltd

Erscheinungsjahr

1977

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Previous studies of human congenital immunodeficiency states and in vitro observations of lymphocyte response to mitogens have implicated two purine salvage pathway enzymes, adenosine deaminase (ADA) and nucleoside phosphorylase (NP), as critical in the normal maturation and/or function of the immune system. Based on this information, ADA and NP activities were examined in a variety of congenital and acquired animal models of dysimmunity. The animals studied herein included: congenitally athymic (nude) mice; congenitally asplenic mice; congenitally athymic-asplenic mice; motheaten mice; New Zealand mice; and Arabian foals with severe combined immunodeficiency. No significant differences in the activities of ADA and NP were observed in any of these animals when compared with either normal littermates or animals with intact immune function. Major species differences were apparent when erythrocyte ADA activity was compared between mice and horses. In contrast, only minor strain alterations in ADA or NP activity were noted between several inbred groups of mice.