Details

Autor(en) / Beteiligte

• Kotler, Donald P.
• Ionescu, Gabriel
• Johnson, Julia A.
• Inada, Yori
• He, Qing
• Engelson, Ellen S.
• Albu, Jeanine B.

Titel

Studies of Adipose Tissue Metabolism in Human Immunodeficiency Virus—Associated Lipodystrophy

Ist Teil von

• Clinical infectious diseases, 2003-09, Vol.37 (Supplement-2), p.S47-S51

Ort / Verlag

United States: The University of Chicago Press

Erscheinungsjahr

2003

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• We studied aspects of metabolism in subcutaneous adipose tissue (SAT) in 40 human immunodeficiency virus (HIV)–infected subjects with and without lipodystrophy and in healthy control subjects. HIV-infected subjects without lipodystrophy had less SAT and visceral adipose tissue (VAT). Glycerol release was higher in both HIV-infected groups, especially those without fat redistribution. Tumor necrosis factor (TNF) release from SAT and serum soluble TNF receptor 2 concentrations were significantly higher in HIV-infected individuals with lipodystrophy. The absolute production of acylation-stimulating protein (ASP) and the percentage conversion of the complement protein to ASP were significantly lower in HIV-infected subjects with lipodystrophy. Further studies are needed to dissect the factors that mediate lipoatrophy in HIV infection.