Details

Autor(en) / Beteiligte

• Kearns, Gregory L
• Abdel-Rahman, Susan M
• Alander, Sarah W
• Blowey, Douglas L
• Leeder, J. Steven
• Kauffman, Ralph E
• Wood, Alastair J.J.

Titel

Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children

Ist Teil von

• The New England journal of medicine, 2003-09, Vol.349 (12), p.1157-1167

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2003

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• For those using drugs to treat infants and children, the integration of developmental pharmacology is crucial to appropriate clinical practice. Changes in metabolic capacity, distribution sites, and organ function all affect the way in which medications are handled in the very young. This review examines the developmental changes that profoundly affect the responses of children to medications and related therapies. Infants and children are far different from adults in terms of societal, psychosocial, behavioral, and medical perspectives. More than 100 years ago Dr. Abraham Jacobi, the father of American pediatrics, recognized the importance of and need for age-appropriate pharmacotherapy when he wrote, “Pediatrics does not deal with miniature men and women, with reduced doses and the same class of disease in smaller bodies, but . . . has its own independent range and horizon.” 1 As our knowledge of normal growth and development has increased in the past several decades, so has our recognition that developmental changes profoundly affect the responses . . .