European journal of biochemistry, 1981-07, Vol.117 (3), p.559-562
1981
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- A Synthetic Ionophore for Ca2+: Studies with Model and Biological Systems
- Ist Teil von
- European journal of biochemistry, 1981-07, Vol.117 (3), p.559-562
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 1981
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We show that the relatively simple β‐diketone, 1,1,1.2,2,3,3‐heptafluoro‐7,7‐dimethyloctane‐d,6‐dione, known as ‘fod’, will solvate Ca2+ ions in an organic phase. In consequence it will transport Ca2+ across phospholipid bilayers. It acts as predicted for a Ca2+‐transporting ionophore in two biological systems: it will stimulate Ca2+‐dependent K+ efflux from human red blood cells, and Cat+‐dependent histamine secretion from rat peritoneal mast cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-2956eISSN: 1432-1033DOI: 10.1111/j.1432-1033.1981.tb06373.xTitel-ID: cdi_proquest_miscellaneous_73656093
- Format
- –
- Schlagworte
- Animals, Calcium - pharmacology, Cholesterol, Erythrocyte Membrane - drug effects, Erythrocyte Membrane - metabolism, Erythrocytes - metabolism, Histamine Release - drug effects, Humans, Hydrocarbons, Fluorinated - pharmacology, Ionophores - pharmacology, Liposomes, Mast Cells - drug effects, Mast Cells - immunology, Phosphatidylcholines, Potassium - blood, Rats