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Gastrointestinal stromal tumors: From a surgical to a molecular approach
International journal of cancer, 2003-11, Vol.107 (2), p.171-176
Rossi, Carlo Riccardo
Mocellin, Simone
Mencarelli, Roberto
Foletto, Mirto
Pilati, Pierluigi
Nitti, Donato
Lise, Mario
2003
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Rossi, Carlo Riccardo
Mocellin, Simone
Mencarelli, Roberto
Foletto, Mirto
Pilati, Pierluigi
Nitti, Donato
Lise, Mario
Titel
Gastrointestinal stromal tumors: From a surgical to a molecular approach
Ist Teil von
International journal of cancer, 2003-11, Vol.107 (2), p.171-176
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Quelle
MEDLINE
Beschreibungen/Notizen
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. These tumors span a wide clinical spectrum from benign to malignant and have long been recognized for their nearly absolute resistance to chemotherapy and radiation treatment. We reviewed the worldwide experience on GIST diagnosis, prognosis and treatment and describe our own series. PubMed was searched for references using the terms gastrointestinal stromal tumor, GIST and gastrointestinal sarcoma. Recent reports were given emphasis because GIST is a novel clinical entity and older published work on gastrointestinal sarcomas might be contaminated with other histologic tumor types. At present, surgery is the standard treatment for primary resectable GIST. To increase the activity of conventional chemotherapeutic agents, locoregional therapies are being implemented in the clinical setting. A major breakthrough is the development of a new class of anticancer agents targeting tumor‐specific molecular abnormalities. Preliminary results on administration of imatinib mesylate, a signal transduction inhibitor, are particularly encouraging, showing potent activity of this drug against metastatic GIST. Molecular targeting of the critical pathogenetic mechanism underlying GIST might not only revolutionize the strategy to treat locally advanced and metastatic GIST but also improve disease control after macroscopically radical surgery. © 2003 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.11374
Titel-ID: cdi_proquest_miscellaneous_73611724
Format
–
Schlagworte
Antineoplastic Agents - therapeutic use
,
Biological and medical sciences
,
Diagnosis, Differential
,
Gastroenterology. Liver. Pancreas. Abdomen
,
Gastrointestinal Neoplasms - pathology
,
Gastrointestinal Neoplasms - surgery
,
Gastrointestinal Neoplasms - therapy
,
gastrointestinal stromal tumor
,
Humans
,
Medical sciences
,
Prognosis
,
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
,
Stromal Cells - pathology
,
Tumors
,
tyrosine kinase inhibitor
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