Neuroscience letters, 2003-09, Vol.349 (1), p.58-62
2003
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- Autor(en) / Beteiligte
- Titel
- Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy
- Ist Teil von
- Neuroscience letters, 2003-09, Vol.349 (1), p.58-62
- Ort / Verlag
- Shannon: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Changes in the structure and function of inhibitory GABA A receptors may contribute to epileptogenesis. We have used the in situ hybridization technique to study GABA A receptor α2, α4, β3 and γ2 subunit mRNA expression in the hippocampus of spontaneously seizing rats with chronic temporal lobe epilepsy. In control rats, all four subunit mRNAs were expressed in the hippocampal subregions but the intensity of expression varied significantly between the subfields. In epileptic rats, α2 expression was decreased in CA3c, and α4 in CA1, but β3 was increased in all subregions, in particular in the granule cell layer. Our results suggest that GABA A receptor undergoes region selective subunit changes during epileptogenesis in the hippocampus of rats with chronic temporal lobe epilepsy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3940eISSN: 1872-7972DOI: 10.1016/S0304-3940(03)00735-3Titel-ID: cdi_proquest_miscellaneous_73607135
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Chronic Disease, Chronic epilepsy, Disease Models, Animal, Epilepsy - genetics, Epilepsy - metabolism, Epilepsy - physiopathology, Epilepsy, Temporal Lobe - genetics, Epilepsy, Temporal Lobe - metabolism, Epilepsy, Temporal Lobe - physiopathology, Epileptogenesis, GABA A receptor, gamma-Aminobutyric Acid - metabolism, Genetic Predisposition to Disease - genetics, Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy, Hippocampus, Hippocampus - metabolism, Hippocampus - physiopathology, In situ hybridization, Male, Medical sciences, Nervous system (semeiology, syndromes), Neural Inhibition - genetics, Neurology, Protein Subunits - genetics, Rats, Rats, Sprague-Dawley, Receptors, GABA-A - genetics, RNA, Messenger - metabolism