Details

Autor(en) / Beteiligte

• Postiglione, L.
• Di Domenico, G.
• Ramaglia, L.
• Montagnani, S.
• Salzano, S.
• Di Meglio, F.
• Sbordone, L.
• Vitale, M.
• Rossi, G.

Titel

Behavior of SaOS-2 Cells Cultured on Different Titanium Surfaces

Ist Teil von

• Journal of dental research, 2003-09, Vol.82 (9), p.692-696

Ort / Verlag

United States: SAGE Publications

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• Surface properties may affect the clinical outcome of titanium dental implants. The aim of the present study was to investigate the effects of 3 different titanium surfaces—smooth (S), sandblasted (SB), and titanium plasma-sprayed (TPS)—on proliferation, differentiation, and apoptosis of human osteoblast-like cells, SaOS-2. Cell proliferation was significantly (p < 0.05) higher on the S surface, and synthesis of extracellular matrix proteins was more abundant on TPS and SB than on S surfaces. Analysis of integrin receptors showed a higher expression of α2, α5, αVβ3, and ß1 on TPS as compared with SB and S surfaces. An increase in alkaline phosphatase activity was detected only on SB and TPS surfaces. Analysis of cell apoptosis did not demonstrate any significant difference among the 3 different surfaces. The results indicate that titanium surface topography affects proliferation and differentiation of osteoblast-like SaOS-2 cells, suggesting that surface properties might be important for bone response around dental implants in vivo.