Details

Autor(en) / Beteiligte

• Wang, Wen-Bo
• Lu, Sheng-Mei
• Yang, Peng-Yu
• Han, Xiu-Wen
• Zhou, Yong-Gui

Titel

Highly Enantioselective Iridium-Catalyzed Hydrogenation of Heteroaromatic Compounds, Quinolines

Ist Teil von

• Journal of the American Chemical Society, 2003-09, Vol.125 (35), p.10536-10537

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• The highly enantioselective hydrogenation of quinoline derivatives is developed using [Ir(COD)Cl]2/(R)-MeO-Biphep/I2 system, and this methodology has been applied to the asymmetric synthesis of three naturally occurring alkaloids angustureine, galipinine, and cuspareine. This method provided an efficient access to a variety of optically active tetrahydroquinolines with up to 96% ee.