Details

Autor(en) / Beteiligte

• Willoughby, John O.
• Pope, Kenneth J.
• Eaton, Vaughn

Titel

Nicotine as an Antiepileptic Agent in ADNFLE: An N‐of‐One Study

Ist Teil von

• Epilepsia (Copenhagen), 2003-09, Vol.44 (9), p.1238-1240

Ort / Verlag

350 Main Street , Malden , MA 02148 , U.S.A: Blackwell Science Inc

Erscheinungsjahr

2003

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Purpose: To test nicotine patch treatment for a patient with a defined mutation for autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) whose seizures were refractory to standard antiepileptic therapy. Methods: Open and double‐blind trials of nicotine patches in an “n‐of‐one” study. The double‐blind trial comprised periods during which either placebo or nicotine patches were each used for three periods of 2 weeks, randomized in a double‐blind manner. Results: In an open study, nicotine patches reduced seizures from 1.65 ± 2.36 to 0.01 ± 0.0 seizures per day (p < 0.0001). In a double‐blinded placebo‐controlled phase, the average frequency of seizures on nicotine versus placebo was 0 ± 0 versus 0.56 ± 1.14 seizures per day (p < 0.0001). Conclusions: Nicotine patches may be of benefit to some individuals with ADNFLE.