Details

Autor(en) / Beteiligte

• PELLEGRINO, B
• TERRIER-LACOMBE, M. J
• PACQUEMENT, H
• VANNIER, J. P
• LAMBILLIOTE, C
• COUILLAULT, G
• BABIN-BOILLETOT, A
• THURET, I
• DEMEOCQ, F
• LEVERGER, G
• DELSOL, G
• LANDMAN-PARKER, J
• OBERLIN, O
• LEBLANC, T
• PEREL, Y
• BERTRAND, Y
• BEARD, C
• EDAN, C
• SCHMITT, C
• PLANTAZ, D

Titel

Lymphocyte-Predominant Hodgkin’s Lymphoma in Children: Therapeutic Abstention After Initial Lymph Node Resection—A Study of the French Society of Pediatric Oncology

Ist Teil von

• Journal of clinical oncology, 2003-08, Vol.21 (15), p.2948-2952

Ort / Verlag

Baltimore, MD: American Society of Clinical Oncology

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• To clarify treatment strategy for lymphocyte-predominant Hodgkin's lymphoma (LPHL), the French Society of Pediatric Oncology initiated a prospective, nonrandomized study in 1988. Patients received either standard treatment for Hodgkin's lymphoma or were not treated beyond initial adenectomy. From 1988 to 1998, 27 patients were available for study. Twenty-four patients were male, and median age was 10 years (range, 4 to 16 years). Twenty-two, two, and three patients had stage I, II, and III disease, respectively. Thirteen patients (stage I, n = 11; stage III, n = 2) received no further treatment after initial surgical adenectomy (SA). Fourteen patients received combined treatment (CT; n = 10), involved-field radiotherapy alone (n = 1), or chemotherapy alone (n = 3). The two groups were comparable for clinical status, treatment, and follow-up. Twenty-three of 27 patients achieved complete remission (CR). With a median follow-up time of 70 months (range, 32 to 214 months), overall survival to date is 100%, and overall event-free survival (EFS) is 69% +/- 10% (SA, 42% +/- 16%; CT, 90% +/- 8.6%; P <.04). If we considered only the patients in CR after initial surgery (n = 12), EFS was no longer significantly different between the two groups. Patients with residual mass after initial surgery (n = 15) had worse EFS if they did not receive complementary treatment (P <.05). Although based on a small number of patients, our study showed that (1). no further therapy is a valid therapeutic approach in LPHL patient in CR after initial lymph node resection, and (2). complementary treatment diminishes relapse frequency but has no impact on survival.