Details

Autor(en) / Beteiligte

• Hunter, Christopher A
• Jones, Philip S
• Tiger, Pascale M N
• Tomas, Salvador

Titel

New building blocks for the assembly of sequence selective molecular zippers

Ist Teil von

• Chemical communications (Cambridge, England), 2003-01 (14), p.1642-1643

Ort / Verlag

England

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• Synthetic H-bonded molecular zippers contain no sequence information that can be used to engineer the selective binding interactions characteristic of biopolymers; reversing the sense of the amide bonds in the two binding partners generates a new orthogonal recognition motif and the mutually complementary binding partners form complexes an order of magnitude more stable than the corresponding mismatch complexes.