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Cellular prion protein function in copper homeostasis and redox signalling at the synapse
Ist Teil von
Journal of neurochemistry, 2003-08, Vol.86 (3), p.538-544
Ort / Verlag
Oxford, UK: Blackwell Science Ltd
Erscheinungsjahr
2003
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
The fundamental physiological function of native cellular prion (PrPC) remains unknown. Herein, the most salient observations as regards prion physiology are critically evaluated. These include: (i) the role of PrPC in copper homeostasis, particularly at the pre‐synaptic membrane; (ii) involvement of PrPC in neuronal calcium disturbances; and (iii) the neuroprotective properties of PrPC in response to copper and oxidative stress. Ultimately, a tentative hypothesis of basic prion function is derived, namely that PrPC acts as a sensor for copper and/or free radical stimuli, thereby triggering intracellular calcium signals that finally translate into modulation of synaptic transmission and maintenance of neuronal integrity.