Clinical infectious diseases, 2003-07, Vol.37 (2), p.302-306
2003
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- Autor(en) / Beteiligte
- Titel
- Clinical tuberculosis in 2 of 3 siblings with interleukin-12 receptor beta1 deficiency
- Ist Teil von
- Clinical infectious diseases, 2003-07, Vol.37 (2), p.302-306
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2003
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- We describe 3 siblings with interleukin-12 receptor beta1 (IL-12Rbeta1) deficiency, a known genetic etiology of clinical disease caused by infection with poorly virulent mycobacteria, such as mycobacteria found in bacille Calmette-Guérin (BCG) vaccines and environmental nontuberculous mycobacteria (NTM). One child had disseminated tuberculosis, the second had extraintestinal salmonellosis and pulmonary tuberculosis, and the third remained asymptomatic. IL-12Rbeta1 deficiency should be considered as a diagnosis in patients with severe salmonellosis or tuberculosis, even if they do not have disease due to BCG or NTM.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1537-6591Titel-ID: cdi_proquest_miscellaneous_73478785
- Format
- –
- Schlagworte
- Adolescent, BCG Vaccine, Child, Child, Preschool, Female, Humans, Infant, Mycobacterium, Receptors, Interleukin - deficiency, Receptors, Interleukin - genetics, Receptors, Interleukin - metabolism, Receptors, Interleukin-12, Salmonella Infections - genetics, Salmonella Infections - metabolism, Salmonella Infections - physiopathology, Tuberculosis - genetics, Tuberculosis - metabolism, Tuberculosis - physiopathology