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In order to discriminate choriocarcinoma from invasive mole, development of a monoclonal antibody that recognizes specifically the abnormal biantennary oligosaccharides is required. As a first step of this line of study, the usefulness and the limit of a novel method to produce monoclonal antibodies directed to N-linked sugar chains of glycoproteins with the use of chemically synthesized oligosaccharides is reported in this paper.