Details

Autor(en) / Beteiligte

• Alizadeh, Mehdi
• Babron, Marie-Claude
• Birebent, Brigitte
• Matsuda, Fumihiko
• Quelvennec, Erwann
• Liblau, Roland
• Cournu-Rebeix, Isabelle
• Momigliano-Richiardi, Patricia
• Sequeiros, Jorge
• Yaouanq, Jacqueline
• Genin, Emmanuelle
• Vasilescu, Alexandre
• Bougerie, Héloise
• Trojano, Maria
• Martins Silva, Berta
• Maciel, Patricia
• Clerget-Darpoux, Françoise
• Clanet, Michel
• Edan, Gilles
• Fontaine, Bertrand
• Semana, Gilbert

Titel

Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients

Ist Teil von

• Annals of neurology, 2003-07, Vol.54 (1), p.119-122

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2003

Link zum Volltext

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA‐DRB1*1501‐DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte‐associated antigen 4 (CTLA‐4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family‐based studies including 610 multiple sclerosis family trios. Ann Neurol 2003;54:119–122