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This Letter describes the design of stable triphosphate analogues of AZT using molecular modelling, their synthesis and their use for producing anti AZT-TP antibodies for developing an immunoassay for TDM.
Triphosphates anabolites are the active chemical species of nucleosidic reverse transcriptase inhibitors in HIV-therapy. Herein, we describe (i) the design of stable triphosphate analogues of AZT using molecular modelling, (ii) their synthesis and (iii) their use for producing anti AZT-TP antibodies in the aim of developing an immunoassay for therapeutic drug monitoring.