The FEBS journal, 2010-01, Vol.277 (1), p.74-80
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer
- Ist Teil von
- The FEBS journal, 2010-01, Vol.277 (1), p.74-80
- Ort / Verlag
- Oxford, UK: Oxford, UK : Blackwell Publishing Ltd
- Erscheinungsjahr
- 2010
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Death-associated protein kinase (DAPK) is a pro-apoptotic serine/threonine protein kinase that is dysregulated in a wide variety of cancers. The mechanism by which this occurs has largely been attributed to promoter hypermethylation, which results in gene silencing. However, recent studies indicate that DAPK expression can be detected in some cancers, but its function is still repressed, suggesting that DAPK activity can be subverted at a post-translational level in cancer cells. This review will focus on recent data describing potential mechanisms that may alter the expression, regulation or function of DAPK.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1742-464XeISSN: 1742-4658DOI: 10.1111/j.1742-4658.2009.07414.xTitel-ID: cdi_proquest_miscellaneous_734233091
- Format
- –
- Schlagworte
- Apoptosis Regulatory Proteins - genetics, Apoptosis Regulatory Proteins - physiology, Calcium-Calmodulin-Dependent Protein Kinases - genetics, Calcium-Calmodulin-Dependent Protein Kinases - physiology, Cancer, Cellular biology, CpG methylation, DAPK, Death-Associated Protein Kinases, Epigenesis, Genetic, ERK-mitogen-activated protein kinase, Gene expression, Germ-Line Mutation, Humans, Kinases, Models, Biological, neoplasms, Neoplasms - drug therapy, Neoplasms - enzymology, Neoplasms - genetics, Polymorphism, Genetic, post-translational regulation, Protein Processing, Post-Translational, Signal transduction, Signal Transduction - physiology