Details

Autor(en) / Beteiligte

• Myers, Catherine
• Posfay-Barbe, Klara M
• Aebi, Christoph
• Cheseaux, Jean-Jacques
• Kind, Christian
• Rudin, Christoph
• Nadal, David
• Siegrist, Claire-Anne

Titel

Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland

Ist Teil von

• The Pediatric infectious disease journal, 2009-11, Vol.28 (11), p.996-1001

Ort / Verlag

United States

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Human immunodeficiency virus (HIV)-infected children are at increased risk of infections caused by vaccine preventable pathogens, and specific immunization recommendations have been issued. A prospective national multicenter study assessed how these recommendations are followed in Switzerland and how immunization history correlates with vaccine immunity. Among 87 HIV-infected children (mean age: 11.1 years) followed in the 5 Swiss university hospitals and 1 regional hospital, most (76%) had CD4 T cells >25%, were receiving highly active antiretroviral treatment (79%) and had undetectable viral load (60%). Immunization coverage was lower than in the general population and many lacked serum antibodies to vaccine-preventable pathogens, including measles (54%), varicella (39%), and hepatitis B (65%). The presence of vaccine antibodies correlated most significantly with having an up-to-date immunization history (P<0.05). An up-to-date immunization history was not related to age, immunologic stage, or viremia but to the referral medical center. All pediatricians in charge of HIV-infected children are urged to identify missing immunizations in this high-risk population.