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Toll-like receptors and aseptic loosening of hip endoprosthesis-a potential to respond against danger signals?
Journal of orthopaedic research, 2010-02, Vol.28 (2), p.184-190
Lähdeoja, Tuomas
Pajarinen, Jukka
Kouri, Vesa-Petteri
Sillat, Tarvo
Salo, Jari
Konttinen, Yrjö T.
2010
Details
Autor(en) / Beteiligte
Lähdeoja, Tuomas
Pajarinen, Jukka
Kouri, Vesa-Petteri
Sillat, Tarvo
Salo, Jari
Konttinen, Yrjö T.
Titel
Toll-like receptors and aseptic loosening of hip endoprosthesis-a potential to respond against danger signals?
Ist Teil von
Journal of orthopaedic research, 2010-02, Vol.28 (2), p.184-190
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Bacterial remnants and subclinical biofilms residing on prosthesis surfaces have been speculated to play a role in hip implant loosening by opsonizing otherwise relatively inert wear particles. The innate immune system recognizes these microbial pathogen‐associated molecular patterns (PAMPs) using Toll‐like receptors (TLRs). Our objective was to evaluate the possible presence of TLRs in aseptic synovial membrane‐like interface tissue. Bacterial culture‐negative, aseptic (n = 4) periprosthetic synovial membrane‐like tissue was compared to osteoarthritis synovial membrane (n = 5) for the presence of cells positive for all known human functional TLRs, stained using specific antibodies by immunohistochemistry, and evaluated using morphometry. In comparison to osteoarthtritic synovium, the number of TLR‐positive cells was found to be increased in the aseptic setting, reflecting the considerable macrophage infiltration to the tissues investigated. Thus aseptic periprosthetic tissue seems to be very reactive to PAMPs. It has been recently recognized that TLR do not only respond to traditional PAMPs, but also to endogenous alarmings or danger signals released from necrotic and activated cells. Alarming‐TLR interaction in the periprosthetic tissue might be a novel mechanism of aseptic loosening of endoprosthesis. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:184–190, 2010
Sprache
Englisch
Identifikatoren
ISSN: 0736-0266
eISSN: 1554-527X
DOI: 10.1002/jor.20979
Titel-ID: cdi_proquest_miscellaneous_734203368
Format
–
Schlagworte
Aged
,
Aged, 80 and over
,
Arthroplasty, Replacement, Hip - adverse effects
,
Arthroplasty, Replacement, Hip - instrumentation
,
Case-Control Studies
,
Female
,
foreign-body reaction
,
Foreign-Body Reaction - etiology
,
Foreign-Body Reaction - immunology
,
Hip Joint - immunology
,
Hip Joint - pathology
,
Hip Joint - surgery
,
hip prosthesis
,
Hip Prosthesis - adverse effects
,
Humans
,
lipopolysaccharide
,
Macrophages - immunology
,
Male
,
Middle Aged
,
Osteoarthritis - immunology
,
Osteoarthritis - pathology
,
Osteoarthritis - surgery
,
Prosthesis Failure
,
Synovial Membrane - immunology
,
Synovial Membrane - pathology
,
Toll-like receptors
,
Toll-Like Receptors - immunology
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