Details

Autor(en) / Beteiligte

• Mehta, Ashok V.
• Chidambaram, Balasubrahmanyam
• Rice, Peter J.

Titel

Pharmacokinetics of Nadolol in Children with Supraventricular Tachycardia

Ist Teil von

• Journal of clinical pharmacology, 1992-11, Vol.32 (11), p.1023-1027

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

1992

Quelle

MEDLINE

Beschreibungen/Notizen

• The pharmacokinetics of intravenous and oral nadolol, a long‐acting β‐adrenoceptor blocking agent, were investigated in six children receiving the drug for treatment of supraventricular tachycardia. In the youngest patient (age 3 months), no distribution phase was seen. In children younger than 22 months of age, nadolol is more rapidly eliminated (t1/2 = 4.3 hours or less) than in older children, in whom elimination is more similar to that in adults (t1/2 ∼ 7.3–15.7 hours). After intravenous administration, nadolol displayed two‐compartment pharmacokinetics with a distribution phase (t1/22 = 0.2–1.1 hours) followed by elimination. Large changes in nadolol pharmacokinetics may occur during the first year of life. Nadolol should be used cautiously in infants.