Details

Autor(en) / Beteiligte

• Liu, Yang
• Li, Yun-ming
• Tian, Rui-feng
• Liu, Wei-ping
• Fei, Zhou
• Long, Qian-fa
• Wang, Xiao-an
• Zhang, Xiang

Titel

The expression and significance of HIF-1alpha and GLUT-3 in glioma

Ist Teil von

• Brain research, 2009-12, Vol.1304, p.149-154

Ort / Verlag

Netherlands

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• HIF-1alpha plays an indispensable role in tumor formation and histogenesis. Target genes involved in glucose transport are acutely transactivated by HIF-1alpha. GLUT-3 protein is the rate-limiting factor related to glucose transport, which is classified as brain-type glucose transporter. This study was the initial one aiming to probe into the co-expression and clinical significance of HIF-1alpha and GLUT-3 in glioma. One hundred and twenty cases of glioma tissues and ten human normal cerebral tissues decompressed in glioma excision were examined using immunohistochemistry and Western blot. The expression of HIF-1alpha and GLUT-3 increased gradually with the increase of pathological grade of glioma, respectively. There was significant difference in the expression of HIF-1alpha and GLUT-3 in every two groups, respectively. There was a positive correlation between HIF-1alpha and GLUT-3. In conclusion, the expression of HIF-1alpha and GLUT-3 in glioma was correlated significantly with tumors' pathological grade, which can be taken as a pair of useful markers for predicting the biological behavior of glioma.