The Journal of immunology (1950), 2009-11, Vol.183 (10), p.6320-6329
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling
- Ist Teil von
- The Journal of immunology (1950), 2009-11, Vol.183 (10), p.6320-6329
- Ort / Verlag
- United States: Am Assoc Immnol
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Th cell differentiation is precisely regulated by thousands of genes at different stages. In the present study, we demonstrate that Dec2, a transcription factor belonging to the bHLH (basic helix-loop-helix) superfamily, is progressively induced during the course of Th2 differentiation, especially at the late stage. The up-regulated Dec2 can strongly promote Th2 development under Th2-inducing conditions, as evidenced by retrovirus-mediated gene transfer or transgenic manipulation. In addition, an enhancement of Th2 responses is also detectable in Dec2 transgenic mice in vivo. Conversely, RNA interference-mediated suppression of endogenous Dec2 could attenuate Th2 differentiation. Finally, we show that the enhanced Th2 development is at least in part due to substantial up-regulation of CD25 expression elicited by Dec2, thereby resulting in hyperresponsiveness to IL-2 stimulation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-1767eISSN: 1550-6606DOI: 10.4049/jimmunol.0900975Titel-ID: cdi_proquest_miscellaneous_734127938
- Format
- –
- Schlagworte
- Animals, CD4-Positive T-Lymphocytes - immunology, CD4-Positive T-Lymphocytes - metabolism, Cell Differentiation - immunology, Cytokines - immunology, Cytokines - metabolism, Female, Interleukin-2 - immunology, Interleukin-2 - metabolism, Interleukin-4 - immunology, Interleukin-4 - metabolism, Lung - immunology, Lung - metabolism, Lung - pathology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Ovalbumin - immunology, Receptors, Interleukin-2 - immunology, Receptors, Interleukin-2 - metabolism, RNA, Small Interfering - immunology, RNA, Small Interfering - metabolism, Signal Transduction - immunology, STAT6 Transcription Factor - genetics, STAT6 Transcription Factor - immunology, STAT6 Transcription Factor - metabolism, Th2 Cells - immunology, Th2 Cells - metabolism, Transcription Factors - genetics, Transcription Factors - immunology, Transcription Factors - metabolism, Transfection, Up-Regulation - immunology