Details

Autor(en) / Beteiligte

• Sun, Yongchao
• Yuan, Shuguang
• Xu, Xiangqing

Titel

Expression of MCP-1 in renal tissues of patients with IgA nephropathy

Ist Teil von

• Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2009-10, Vol.34 (10), p.1023-1028

Ort / Verlag

China

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• To investigate the differential expression of monocyte chemoattractant protein-1 (MCP-1) in renal biopsy tissues of patients with IgA nephropathy, and to analyse the association between these 2 markers and their effect on various pathologic types of IgA nephropathy. According to pathologic type, 88 renal biopsy tissues of patients with IgA nephropathy were divided into 4 groups:a minimal change group,a mesangial proliferative glomerulonephritis group, a focal sclerosing glomerulonephritis group, and a diffused sclerosing glomerulonephritis group. Immunohistochemical staining was used to detect the in situ expression of MCP-1 and CD68 on renal biopsy tissues. The expression levels were semi-quantified by image analysis and clinical data were collected from the patients. The differences in glomerular MCP-1 expressions were not statistically significant among all groups, while the tubulointerstitial MCP-1 expressions were statistically different among the 4 groups, with the average scores of 1.43+/-0.60, 5.98+/-