Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6780-6783
- Tarver, James E.
- Jessop, Theodore C.
- Carlsen, Marianne
- Augeri, David J.
- Fu, Qinghong
- Healy, Jason P.
- Heim-Riether, Alexander
- Xu, Amy
- Taylor, Jerry A.
- Shen, Min
- Keyes, Philip E.
- David Kimball, S.
- Yu, Xuan-Chuan
- Miranda, Maricar
- Liu, Qingyun
- Swaffield, Jonathan C.
- Nouraldeen, Amr
- Wilson, Alan G.E.
- Finch, Rick
- Jhaver, Kanchan
- Foushee, Ann Marie DiGeorge
- Anderson, Steve
- Oravecz, Tamas
- Carson, Kenneth G.
2009
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Tarver, James E.
- Jessop, Theodore C.
- Carlsen, Marianne
- Augeri, David J.
- Fu, Qinghong
- Healy, Jason P.
- Heim-Riether, Alexander
- Xu, Amy
- Taylor, Jerry A.
- Shen, Min
- Keyes, Philip E.
- David Kimball, S.
- Yu, Xuan-Chuan
- Miranda, Maricar
- Liu, Qingyun
- Swaffield, Jonathan C.
- Nouraldeen, Amr
- Wilson, Alan G.E.
- Finch, Rick
- Jhaver, Kanchan
- Foushee, Ann Marie DiGeorge
- Anderson, Steve
- Oravecz, Tamas
- Carson, Kenneth G.
- Titel
- 5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6780-6783
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A series of potent piperidine-linked cytosine derivatives were prepared as inhibitors of deoxycytidine kinase (dCK). Compound 9h was discovered to be a potent inhibitor of dCK and shows a good combination of cellular potency and pharmacokinetic parameters. Compound 9h blocks the incorporation of radiolabeled cytosine into mouse T-cells in vitro, as well as in vivo in mice following a T-cell challenge.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2009.09.082Titel-ID: cdi_proquest_miscellaneous_734123242
- Format
- –
- Schlagworte
- Animals, Antineoplastic agents, Biological and medical sciences, Bones, joints and connective tissue. Antiinflammatory agents, Cancer, Deoxycytidine kinase, Deoxycytidine Kinase - antagonists & inhibitors, Drug Design, Flucytosine - chemical synthesis, Flucytosine - chemistry, Flucytosine - pharmacology, General aspects, Humans, Immunology, Immunomodulators, Medical sciences, Mice, Molecular Structure, Pharmacokinetics, Pharmacology. Drug treatments, Protein Kinase Inhibitors - chemical synthesis, Protein Kinase Inhibitors - chemistry, Protein Kinase Inhibitors - pharmacology, Stereoisomerism, Structure-Activity Relationship, Virology