Fertility and sterility, 2009-11, Vol.92 (5), p.1794-1798
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin β subunits, and anti-Müllerian hormone in human granulosa cells
- Ist Teil von
- Fertility and sterility, 2009-11, Vol.92 (5), p.1794-1798
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2009
- Quelle
- ScienceDirect
- Beschreibungen/Notizen
- Immunohistochemical staining using human normal ovaries showed that bone morphogenetic protein-6 (BMP-6) was abundantly present in the granulosa cells (GC) of healthy tertiary follicles but not in atretic follicles. An in vitro study showed that BMP-6 induced gene expression of FSH receptor, inhibin/activin β subunits, and anti-Müllerian hormone (AMH) in human GCs, suggesting that BMP-6 is an important mediator to support healthy follicle growth in the human ovary.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0015-0282eISSN: 1556-5653DOI: 10.1016/j.fertnstert.2009.05.004Titel-ID: cdi_proquest_miscellaneous_734116825
- Format
- –
- Schlagworte
- Adult, Anti-Mullerian Hormone - genetics, Anti-Mullerian Hormone - metabolism, Bone Morphogenetic Protein 6 - metabolism, Bone Morphogenetic Protein 6 - pharmacology, Bone Morphogenetic Protein 6 - physiology, Cells, Cultured, Female, Gene Expression Regulation - drug effects, Granulosa Cells - drug effects, Granulosa Cells - metabolism, Humans, Inhibin-beta Subunits - genetics, Inhibin-beta Subunits - metabolism, Internal Medicine, Obstetrics and Gynecology, Ovarian Follicle - drug effects, Ovarian Follicle - metabolism, Ovarian Follicle - physiology, Ovary - drug effects, Ovary - metabolism, Receptors, FSH - genetics, Receptors, FSH - metabolism